Iboga Worldwide
New research on iboga and ibogaine
Peer-reviewed papers and preprints indexed by PubMed that study iboga, ibogaine or noribogaine: clinical results, safety and pharmacology, reviews and mechanism work. Refreshed daily; every entry links to its PubMed record, with a one-line note on what the paper reports.
Latest entry: September 26, 2026
2026
Letter to the Editor for "Evaluating Pharmacogenomic Prescription Data in the Military Health System": Medication-Induced CYP2D6 Inhibition Reveals a Screening Gap in Proxy-Defined Ibogaine Candidates
A letter in Military Medicine reports that medication-induced CYP2D6 inhibition reveals a screening gap among proxy-defined ibogaine candidates in the Military Health System.
Adverse Health Outcomes of Psilocybin, LSD, MDMA, Ibogaine, and 5-MeO-DMT
A JAMA Network Open paper reviews adverse health outcomes associated with psilocybin, LSD, MDMA, ibogaine and 5-MeO-DMT.
Ibogaine as a double-edged sword: Developmental cardiotoxicity and neurobehavioral alterations in zebrafish
A zebrafish study reports developmental cardiotoxicity and neurobehavioral alterations following ibogaine exposure.
Feasibility, safety and preliminary effects of ibogaine in patients with moderate and severe alcohol use disorder: a pilot, open-label study
A pilot open-label study reports feasibility, safety and preliminary effects of ibogaine in patients with moderate and severe alcohol use disorder.
Sustained abstinence in severe ketamine use disorder following ibogaine treatment case report
A case report describes sustained abstinence from severe ketamine use disorder after ibogaine treatment.
Toward a nuanced framework for the medical development of ibogaine and its analogues and derivatives: implications for psychopharmacology
A review proposes a framework for the medical development of ibogaine and its analogues and derivatives.
Non-adherence to registration further undermines the methodologically weak Stanford University Magnesium-Ibogaine Study
A commentary argues the Stanford magnesium-ibogaine study deviated from its registration and is methodologically weak.
Clinical improvement following an integrative iboga microdosing protocol in post-concussive and hypoxic brain injury syndromes: a case series
A case series reports clinical improvement in post-concussive and hypoxic brain injury after an iboga microdosing protocol.
Ibogaine in the Vet Brain: Changes in Brain Metabolism and Connectivity After Ibogaine Administration in Veterans With Traumatic Brain Injury
A study reports changes in brain metabolism and connectivity after ibogaine in veterans with traumatic brain injury.
Thirty Years of Ibogaine Research: A Literature Review on Clinical Perspectives
A literature review summarizes thirty years of clinical ibogaine research.
Exploring the Use of Ibogaine in Opioid Recovery: Insights from Lived Experience
A qualitative study explores lived experience of ibogaine use in opioid recovery.
Ibogaine induces juvenile-like plasticity and modulates functional and structural regulators of plasticity in the adult mouse visual cortex
A mouse study finds ibogaine induces juvenile-like plasticity in the adult visual cortex.
From monotherapy to sequential models: An updated scoping review on ibogaine's role in treatment for psychiatric disorders
An updated scoping review examines ibogaine's role in treating psychiatric disorders, from monotherapy to sequential models.
US speeds up research into mind-altering drugs - including mysterious 'ibogaine'
Nature reports the United States accelerating research into psychedelic drugs, including ibogaine.
Oxa-noribogaine reduces alcohol drinking through aversion learning and by altering glutamatergic activity in the mPFC
A preprint reports oxa-noribogaine reduces alcohol drinking via aversion learning and altered mPFC glutamatergic activity.
Psilocybin and Ibogaine in Cocaine-Seeking: Extinction Enhancement Without Relapse Prevention
A rodent study finds psilocybin and ibogaine enhance extinction of cocaine-seeking without preventing relapse.
Increased cortical thickness and decreased brain age among special operations veterans with blast TBI after a magnesium-ibogaine protocol
A study reports increased cortical thickness and decreased brain age in veterans with blast TBI after magnesium-ibogaine.
Neural Correlates of Ibogaine: Evidence From Functional Neuroimaging of Military Veterans
A functional neuroimaging study of military veterans reports neural correlates of ibogaine.
Ibogaine: Therapeutic Potential, Cardiac Safety, and Translational Perspectives in the Treatment of Substance Use Disorders-A Scoping Review
A scoping review covers ibogaine's therapeutic potential and cardiac safety in substance use disorders.
Accelerated recovery using magnesium ibogaine: characterizing the subjective experience of its rapid healing from neuropsychiatric disorders
A study characterizes subjective experiences of rapid recovery from neuropsychiatric disorders after magnesium ibogaine.
Rare but relevant: Ibogaine and cardiovascular complications-prolonged QT interval and ventricular arrhythmias
A paper addresses QT prolongation and ventricular arrhythmias associated with ibogaine.
Ibogaine for Opioid Use Disorder: An Unrecognized Risk
A paper describes an unrecognized risk of ibogaine use for opioid use disorder.
2025
Deciphering Ibogaine's Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses
Pharmacology study examines how ibogaine modulates multiple transporters at serotonin synapses.
Ibogaine: Revisiting an Ancient Alkaloid for Modern Opioid Dependence
Review revisits ibogaine as a treatment candidate for opioid dependence.
Ibogaine's potential role in supporting reward system recovery across diagnostic boundaries
Review discusses ibogaine's possible role in reward system recovery across multiple psychiatric diagnoses.
Mystical experiences during magnesium-Ibogaine are associated with improvements in PTSD symptoms in veterans
Study links mystical experiences during magnesium-ibogaine treatment to PTSD symptom improvements in veterans.
The Ibogaine Experience Scale (IES): Development and psychometric properties of a multidimensional measure of ibogaine's subjective effects
Researchers develop and validate the Ibogaine Experience Scale measuring subjective effects of ibogaine.
The psychoactive compound ibogaine sex-dependently alters the firing rate and afterhyperpolarization of I(h)-negative neurons in the mouse ventral tegmental area
Mouse study finds ibogaine alters firing of ventral tegmental area neurons differently by sex.
Old Dog, New Tricks: Ibogaine and Its Analogs as Potential Neurotherapeutics
Review examines ibogaine and its analogs as potential neurotherapeutics.
Not Losing Momentum: Cross-Sectional Insights into Ibogaine Clinical Trials
Cross-sectional analysis surveys the landscape of ibogaine clinical trials.
Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis
Case report describes lesion reduction and neural changes after ibogaine treatments for multiple sclerosis.
Efficient and modular synthesis of ibogaine and related alkaloids
Chemists report an efficient modular synthesis of ibogaine and related alkaloids.
A case series of ibogaine toxicity reported to the United Kingdom National Poisons Information Service (NPIS) over a 10-year period
A case series describes ibogaine toxicity cases reported to the UK National Poisons Information Service over ten years.
2024
Dimethyltryptamine (DMT) and ibogaine elicit membrane effects in HEK cells transiently transfected with the human 5-HT2A receptor
A cell study reports membrane effects of DMT and ibogaine in cells expressing the human 5-HT2A receptor.
Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
A study reports oxa-iboga alkaloids lacking cardiac risk while reducing opioid use in animal models.
Ibogaine administration following repeated morphine administration upregulates myelination markers 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin basic protein (MBP) mRNA and protein expression in the internal capsule of Sprague Dawley rats
A rat study reports ibogaine after repeated morphine increases myelination markers in the internal capsule.
Multiple Episodes of Cardiac Arrest Induced by Treatment With Ibogaine: A Case Report
A case report describes multiple cardiac arrests in a patient following ibogaine treatment.
Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT(2A) receptor activation
Non-hallucinogenic iboga-derived compounds relieve neuropathic and visceral pain in mice via 5-HT2A activation.
Ibogaine Induces Cardiotoxic Necrosis in Rats-The Role of Redox Processes
A rat study reports ibogaine causes cardiotoxic necrosis and examines the role of redox processes.
The pharmacokinetics and pharmacodynamics of ibogaine in opioid use disorder patients
A clinical study reports ibogaine pharmacokinetics and pharmacodynamics in patients with opioid use disorder.
Noribogaine acute administration in rats promotes wakefulness and suppresses REM sleep
A rat study reports acute noribogaine promotes wakefulness and suppresses REM sleep.
Psychedelic Therapy: A Primer for Primary Care Clinicians-Ibogaine
A primer reviews ibogaine therapy for primary care clinicians.
Ibogaine therapy in TBI
Nature Neuroscience highlights ibogaine therapy research in traumatic brain injury.
A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets
A transcriptomic study in mice after a single ibogaine dose identifies potential new therapeutic targets.
Magnesium-ibogaine therapy in veterans with traumatic brain injuries
A Nature Medicine study reports outcomes of magnesium-ibogaine therapy in veterans with traumatic brain injuries.
2023
Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico
An open-label study reports prospective data on consecutive ibogaine and 5-MeO-DMT therapy for Special Operations Forces veterans in Mexico.
Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview
A review outlines the main molecular targets of ibogaine and noribogaine linked to their putative anti-addictive effects.
Three Decades of Research on the Development of Ibogaine Treatment of Substance Use Disorders: A Scientometric Analysis
A scientometric analysis maps three decades of research on ibogaine treatment for substance use disorders.
Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion
A case report describes ibogaine reducing severe neuropathic pain from brachial plexus nerve root avulsion.
The Nonclassic Psychedelic Ibogaine Disrupts Cognitive Maps
A study reports that ibogaine disrupts cognitive map representations in an experimental model.
Tabernanthalog Reduces Motivation for Heroin and Alcohol in a Polydrug Use Model
A study reports the ibogaine analog tabernanthalog reduces motivation for heroin and alcohol in a polydrug model.
Identifying setting factors associated with improved ibogaine safety: a systematic review of clinical studies
A systematic review of clinical studies identifies setting factors associated with improved ibogaine safety.
IUPHAR - invited review - Ibogaine - A legacy within the current renaissance of psychedelic therapy
An invited IUPHAR review surveys ibogaine's legacy within the current revival of psychedelic therapy.
Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature
A systematic review summarizes current literature on ibogaine and noribogaine for treating substance use disorders.
2022
Underground ibogaine use for the treatment of substance use disorders: A qualitative analysis of subjective experiences
A qualitative study analyzes subjective experiences of people using ibogaine underground to treat substance use disorders.
What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders
A review examines α3β4 nicotinic receptor inhibitors derived from ibogaine research as potential substance use disorder treatments.
Ibogaine microdosing in a patient with bipolar depression: a case report
A case report describes ibogaine microdosing in a patient with bipolar depression.
Ibogaine and Their Analogs as Therapeutics for Neurological and Psychiatric Disorders
A review covers ibogaine and its analogs as potential therapeutics for neurological and psychiatric disorders.
Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites
A study finds drug transporters P-gp and OATP, not CYP3A4, affect pharmacokinetics of ibogaine and its metabolites.
Tabernaemontana arborea and ibogaine induce paroxysmal EEG activity in freely moving mice: Involvement of serotonin 5-HT(1A) receptors
A mouse study finds ibogaine and Tabernaemontana arborea induce paroxysmal EEG activity involving 5-HT1A receptors.
2021
A systematic literature review of clinical trials and therapeutic applications of ibogaine
A systematic review summarizes clinical trials and therapeutic applications of ibogaine.
Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females
A rat study reports sex-specific ibogaine bioavailability and liver and kidney effects in females.
Response to Luz & Mash on cardiac toxicity of ibogaine
A letter responds to Luz and Mash regarding cardiac toxicity of ibogaine.
Reply to Knuijver et al. on the 'Safety of ibogaine administration in detoxification of opioid-dependent individuals: a descriptive open-label observational study'
Authors reply to Knuijver et al. about their observational study on ibogaine safety in opioid detoxification.
Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice
A mouse study finds ibogaine blocks cue- and drug-induced reinstatement of ethanol conditioned place preference.
The adverse events of ibogaine in humans: an updated systematic review of the literature (2015-2020)
An updated systematic review compiles adverse events of ibogaine in humans reported from 2015 to 2020.
Safety of ibogaine administration in detoxification of opioid-dependent individuals: a descriptive open-label observational study
An open-label observational study describes the safety of ibogaine administration during detoxification of opioid-dependent individuals.
A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans
A study presents a new approach methodology to predict ibogaine- and noribogaine-induced cardiotoxicity in humans.
Evaluating the toxicity and therapeutic potential of ibogaine in the treatment of chronic opioid abuse
A review evaluates toxicity and therapeutic potential of ibogaine for chronic opioid use disorder.
The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs
A review covers the chemistry and neuropharmacology of iboga alkaloids and related analogs.
Death due to consumption of ibogaine: case report
A forensic case report describes a death attributed to ibogaine consumption.
EEG Gamma Band Alterations and REM-like Traits Underpin the Acute Effect of the Atypical Psychedelic Ibogaine in the Rat
A rat study links acute ibogaine effects to EEG gamma band alterations and REM-like traits.
2020
A non-hallucinogenic psychedelic analogue with therapeutic potential
Researchers describe a non-hallucinogenic analogue, derived from ibogaine, with therapeutic potential in animal models.
Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters
Researchers report a tropane-based ibogaine analog that rescues folding-deficient serotonin and dopamine transporters.
Ibogaine therapy for addiction: Consumer views from online fora
Researchers analyze consumer views on ibogaine therapy for addiction posted in online forums.
Psychedelic Treatment for Trauma-Related Psychological and Cognitive Impairment Among US Special Operations Forces Veterans
A study reports outcomes of psychedelic treatment, including ibogaine, for trauma-related impairment among US Special Operations Forces veterans.
A Single Administration of the Atypical Psychedelic Ibogaine or Its Metabolite Noribogaine Induces an Antidepressant-Like Effect in Rats
A rat study finds a single dose of ibogaine or noribogaine produces an antidepressant-like effect.
Quantitative Evaluation of a Mexican and a Ghanaian Tabernaemontana Species as Alternatives to Voacanga africana for the Production of Antiaddictive Ibogan Type Alkaloids
Researchers quantify ibogan alkaloids in Mexican and Ghanaian Tabernaemontana species as alternative sources to Voacanga africana.
Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids
Researchers describe the structural basis of the cycloaddition step in iboga and aspidosperma alkaloid biosynthesis.
2019
Ibogaine Consumption With Seizure-Like Episodes, QTc-Prolongation, and Captured Cardiac Dysrhythmias
A case report describes ibogaine consumption followed by seizure-like episodes, QTc prolongation and recorded cardiac dysrhythmias.
Biosynthesis of an Anti-Addiction Agent from the Iboga Plant
Researchers elucidate the biosynthetic pathway of ibogaine in the iboga plant.
Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport
Structures of serotonin transporter-ibogaine complexes reveal mechanisms of inhibition and transport.
Ibogaine and Subjective Experience: Transformative States and Psychopharmacotherapy in the Treatment of Opioid Use Disorder
A paper examines subjective transformative experiences with ibogaine in treating opioid use disorder.
Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits
An animal study finds ibogaine modifies GDNF and BDNF expression in dopaminergic brain regions.
The paradox of iboga: intoxication by a natural detoxification remedy
A Spanish psychiatry journal paper describes intoxication by iboga used as a detoxification remedy.
2018
Hallucinogen Persisting Perception Disorder After Ibogaine Treatment for Opioid Dependence
A case describes hallucinogen persisting perception disorder following ibogaine treatment for opioid dependence.
A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder
A case report uses SPECT imaging to describe sequential ibogaine and 5-MeO-DMT administration for alcohol use disorder and offers a theoretical rationale.
Ibogaine as a treatment for substance misuse: Potential benefits and practical dangers
A review examines potential benefits and practical dangers of ibogaine as a treatment for substance misuse.
DARK Classics in Chemical Neuroscience: Ibogaine
A review covers ibogaine's chemistry, pharmacology and history in the DARK Classics series.
Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga
Researchers identify a cytochrome P450 and an O-methyltransferase that complete ibogaine biosynthesis in Tabernanthe iboga.
A Mixed-Method Analysis of Persisting Effects Associated with Positive Outcomes Following Ibogaine Detoxification
A mixed-method study analyzes persisting effects linked to positive outcomes after ibogaine detoxification.
Cardiac arrest after ibogaine intoxication
A case report describes cardiac arrest following ibogaine intoxication.
Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes
A paper reports clinical observations and outcomes of ibogaine detoxification in opioid and cocaine users.
Changes in Withdrawal and Craving Scores in Participants Undergoing Opioid Detoxification Utilizing Ibogaine
A study measures changes in withdrawal and craving scores among participants undergoing opioid detoxification with ibogaine.
2017
Breaking the cycle of opioid use disorder with Ibogaine
A paper discusses ibogaine's role in breaking the cycle of opioid use disorder.
Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes and current psychological functioning
A study reports subjective short- and long-term outcomes and psychological functioning after ibogaine treatment for problematic opioid use.
On the relationship between ibogaine and noribogaine
A paper examines the pharmacological relationship between ibogaine and its metabolite noribogaine.
Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes
A study reports detoxification and drug use outcomes after ibogaine treatment for opioid use disorder.
Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study
A twelve-month observational study reports ibogaine treatment outcomes for opioid dependence.
Examination of the Phenomenology of the Ibogaine Treatment Experience: Role of Altered States of Consciousness and Psychedelic Experiences
A study examines altered states and psychedelic experiences in the phenomenology of ibogaine treatment.
Toxicokinetics of ibogaine and noribogaine in a patient with prolonged multiple cardiac arrhythmias after ingestion of internet purchased ibogaine
A case reports toxicokinetics in a patient with prolonged cardiac arrhythmias after ingesting internet-purchased ibogaine.
2016
Ascending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients
A double-blind placebo-controlled trial tests ascending single doses of noribogaine for safety in opioid-dependent patients.
How this index is kept
- PubMed is searched daily for papers whose title or abstract names iboga, ibogaine, noribogaine or Tabernanthe. Each is scored for relevance to readers following this subject and listed with a note written for this index.
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